Increased susceptibility to oxidation of low‐density lipoproteins isolated from patients with systemic sclerosis
- 1 August 1995
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 38 (8) , 1060-1067
- https://doi.org/10.1002/art.1780380807
Abstract
Objective. To examine the resistance to oxidation of low‐density lipoproteins (LDL) from patients with systemic sclerosis (SSc) and primary Raynaud's phenomenon (RP) compared with healthy controls.Methods. Plasma LDL were isolated from patients with diffuse cutaneous and limited cutaneous SSc (dcSSc and lcSSc, respectively), patients with primary RP, and healthy control subjects. The lipoproteins were assessed for their resistance to oxidation in the presence of cupric ions, using spectrophotometric assays.Results. LDL from patients with dcSSc and lcSSc were more susceptible to oxidation than were those from healthy control subjects or patients with RP.Conclusion. Our findings suggest that free radicals may play a role in the pathology of SSc.Keywords
This publication has 38 references indexed in Scilit:
- Modified forms of low‐density lipoprotein and atherosclerosisJournal of Internal Medicine, 1993
- A radical proposal for the pathogenesis of sclerodermaJournal of the American Academy of Dermatology, 1993
- Expression of adhesion proteins involved in cell-cell and cell-matrix interactions in the skin of patients with progressive systemic sclerosisJournal of the American Academy of Dermatology, 1992
- Induction of platelet-derived growth factor chain a gene expression in human smooth muscle cells by oxidized low density lipoproteinsBiochemical and Biophysical Research Communications, 1992
- Induction of T-cell activation by oxidized low density lipoprotein.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1992
- Endothelin, an endothelial‐dependent vasoconstrictor in scleroderma. Enhanced production and profibrotic actionArthritis & Rheumatism, 1991
- Oxidation of cholesterol moiety of low density lipoprotein in the presence of human endothelial cells or Cu+2 ions: Identification of major products and their effectsBiochemical and Biophysical Research Communications, 1991
- Elevated plasma levels of endothelin‐1 in systemic sclerosisArthritis & Rheumatism, 1991
- Endothelial cell cytotoxicity in inflammatory vascular diseases–the possible role of oxidised lipoproteins.Annals of the Rheumatic Diseases, 1985
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976