Structural and Functional Changes in Ribosomes from Ischemic Liver in the Dog: Effects of Short-Term Hepatic Artery Ligation and Hemorrhagic Shock
- 1 January 1980
- journal article
- research article
- Published by S. Karger AG in European Surgical Research
- Vol. 12 (1) , 30-38
- https://doi.org/10.1159/000128107
Abstract
Structure and function of isolated liver ribosomes from 10 dogs subjected to 1 h of hepatic artery ligation (HAL) or hemorrhagic shock were studied. A shift of polyribosomes to monoribosomes and a decreased capacity to incorporate amino acids into proteins were seen in both experimental conditions. The effects were more pronounced in hemorrhagic shock. Structural and functional changes were reversible after HAL. In the shock experiments a slight increase of the ribosomal activity was seen after reinfusion but the initial values were not reached during the 2 h after the shock period. Some underlying mechanisms of altered ribosomal structure and function in liver ischemia are discussed.Keywords
This publication has 3 references indexed in Scilit:
- Measurement of the incorporation of radioactive amino acids into protein by a filter-paper disk methodArchives of Biochemistry and Biophysics, 1961
- Studies on the Function of Intracellular RibonucleasesThe Journal of cell biology, 1960
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951