Lactic acidosis

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Abstract
A description is presented of the initial clinical and laboratory findings in a group of 46 patients with uncompensated lactic acidosis, ie, with severe metabolic acidosis, not otherwise explained, and with markedly elevated blood lactic acid concentration. These patients are contrasted with 34 severely ill, hospitalized patients, with and without other forms of metabolic acidosis and respiratory alkalosis. Lactic acidosls represents a syndrome of severe metabolic acidosis caused by the accumulation of large amounts of intracellular and extracellular lactic acid. This appears to be the end result of a variety of converging and reinforcing pathways which vary in their significance from individual to individual. It seems likely that the underlying causes may involve both the pathways of energy production and the mechanisms of acid-base balance.[long dash]Authors.

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