Temporal Effects of Shock Wave Lithotripsy
- 1 April 1991
- journal article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 145 (4) , 881-883
- https://doi.org/10.1016/s0022-5347(17)38482-3
Abstract
Previous studies have demonstrated that renal parenchymal injury following extracorporeal shock wave lithotripsy is dependent upon shock wave power as well as the total number of shock waves administered. In order to determine the deleterious effects of temporal versus cumulative doses of shock wave administration, adult female rabbits were divided into five groups receiving either: 1000 shock waves in one session; 2000 shock waves in one session; 2000 shock waves in two sessions, one week apart; unilateral nephrectomy without lithotripsy; or anesthesia only as control population. One month following lithotripsy, renal functional studies for gamma glutamyl transferase and N-acetyl-beta-glucosaminidase revealed persistent enzymuria in the animals treated with 2000 shocks in one session. Pathologic studies in these animals confirmed an increased area of periglomerular and intratubular fibrosis when compared to animals managed by either 1000 shocks or 2000 shocks in divided doses (p less than 0.01). These findings suggest the importance of avoiding single treatments with large doses of shock waves and favor the administration of multiple small-doses of shock waves to minimize renal damage during the treatment of patients with hard or large calculi.Keywords
This publication has 7 references indexed in Scilit:
- Initial EDAP LT-01 Lithotripsy Group Experience in the United StatesJournal of Urology, 1989
- Extracorporeal Shock Wave Lithotripsy Monotherapy: Experience with Piezoelectric Second Generation Lithotriptor in 642 PatientsJournal of Urology, 1989
- Clinical Experience Using the Wolf Piezolith Device at 2 British Stone CentersJournal of Urology, 1989
- Effects of Extracorporeal Shock Wave Lithotripsy on the Structure and Function of Rabbit KidneyJournal of Urology, 1989
- Sonographic Piezoelectric Lithotripsy: More Bang for Your Buck*Journal of Endourology, 1989
- Painless Piezoelectric Extracorporeal LithotripsyJournal of Urology, 1988
- Effect of Extracorporeally Induced High-Energy Shock Waves on the Rabbit Kidney and Ureter: A Morphologic and Functional Study*Journal of Endourology, 1988