Synthesis of D-Psico- and D-Fructofuranosyl Nucleosides.
- 1 January 1984
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 38b (5) , 367-373
- https://doi.org/10.3891/acta.chem.scand.38b-0367
Abstract
The condensation of 6-chloropurine with peracylated psicofuranosyl and fructofuranosyl chlorides, using Yamaoka''s procedure, afforded, respectively, the .beta. and .alpha. anomers of the corresponding purine nucleosides. A similar result was obtained when silylated uracil was reacted with peracylated ketose. The first chemical synthesis of 1-.beta.-D-fructofuranosyluracil was also accomplished from 1-.beta.-D-psicofuranosyluracil via the 2,3''-anhydro derivative. [These types of nucleoside have antibiotic and antitumor properties.].This publication has 3 references indexed in Scilit:
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