SEGREGATION OF HUMAN PERIPHERAL-BLOOD LYMPHOCYTES ACCORDING TO THEIR AFFINITY FOR INSOLUBILIZED HISTAMINE - PRINCIPAL DIFFERENCES BETWEEN MALES AND FEMALES

  • 1 January 1979
    • journal article
    • research article
    • Vol. 38  (1) , 166-174
Abstract
Differences may exist in composition of peripheral blood lymphocytes between males and females. Affinity chromatography of human peripheral mononuclear cells on insolubilized histamine together with staining by fluoresceinated histamine-rabbit serum albumin (HRSA) revealed that males possess a significantly higher proportion of mononuclear cells which bind to HRSA. These results are reflected in sex-related differences in proliferative responses of the HRSA-non-adherent mononuclear cell population to T [thymus-derived] cell-dependent mitogens, antigens and allogeneic mononuclear cells.

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