Synthesis, sar and pharmacology of CP-293,019: A potent, selective dopamine D4 receptor antagonist
- 1 April 1998
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 8 (7) , 725-730
- https://doi.org/10.1016/s0960-894x(98)00108-5
Abstract
No abstract availableKeywords
This publication has 8 references indexed in Scilit:
- Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition.Psychopharmacology, 1998
- Schizophrenia and L-745, 870, a novel dopamine D4 receptor antagonistTrends in Pharmacological Sciences, 1997
- The Effects of a Selective D4 Dopamine Receptor Antagonist (L-745,870) in Acutely Psychotic Inpatients With SchizophreniaArchives of General Psychiatry, 1997
- Palladium-Catalyzed Amination of Aryl IodidesThe Journal of Organic Chemistry, 1996
- 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: An Antagonist with High Affinity and Selectivity for the Human Dopamine D4 ReceptorJournal of Medicinal Chemistry, 1996
- Dopamine D4 receptors elevated in schizophreniaNature, 1993
- Synthesis and biological characterization of .alpha.-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogs as potential atypical antipsychotic agentsJournal of Medicinal Chemistry, 1992
- Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapineNature, 1991