Myoclonic spasms during treatment with high doses of intravenous morphine in renal failure
- 1 November 1993
- journal article
- case report
- Published by Wiley in Acta Anaesthesiologica Scandinavica
- Vol. 37 (8) , 780-782
- https://doi.org/10.1111/j.1399-6576.1993.tb03809.x
Abstract
Myoclonic spasms occurred in a patient suffering from renal failure after high doses of continuous intravenous morphine (100 mg/h). The concentrations of morphine, morphine-6-glucuronide and morphine-3-glucuronide (mumol/l) in plasma were: 1.93, 52.06 and 381.8, and in cerebrospinal fluid were: 1.02, 5.86 and 61.82, respectively. The role of morphine and morphine glucuronides in myoclonic spasms is discussed.Keywords
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