Chiral separation of 3,4‐methylenedioxymeth‐ amphetamine and related compounds in clandestine tablets and urine samples by capillary electrophoresis/fluorescence spectroscopy
- 19 March 2003
- journal article
- research article
- Published by Wiley in Electrophoresis
- Vol. 24 (6) , 1097-1104
- https://doi.org/10.1002/elps.200390128
Abstract
The R‐(–)‐ and S‐(+)‐isomers of 3,4‐methylenedioxymethamphetamine (MDMA) and its metabolite 3,4‐methylenedioxyamphetamine (MDA) were prepared, identified by gas chromatography/mass spectrometry (GC/MS) and then used as standards in a series of capillary electrophoresis (CE) experiments. Using these R‐(–)‐ and S‐(+)‐isomers, the distribution of (RS)‐MDA and (RS)‐MDMA stereoisomers in clandestine tablets and suspect urine samples were identified. Several electrophoretic parameters, such as the concentration of β‐cyclodextrin used in the electrophoretic separation and the amount of organic solvents required for the separation, were optimized.Keywords
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