Evaluation of the in-vitro antibacterial activity of Sch 34343

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Abstract
The in-vitro activity (as measured by geometric mean MICs, mg/1) of Sch 34343 against aerobic and anaerobic bacteria was compared with that of 14 other selected β -lactam antibiotics including aztreonam, latamoxef (moxalactam), ceftaadime and imipenem. Sch 34343 had good activity (β -lactamases. It was slightly less potent against strains of Morganella and Serratia (64 mg/1). A very small inoculum effect was observed against strains containing β -lactamases indicating stability. Unlike the third-generation cephalosponns, Sch 34343 had excellent activity (≤0.18 mg/1) against staphylococci, comparable to that of imipenem and ampicillin. While Sch 34343 had equally good potency (0.17 mg/1) against penicillinase-positive staphylococci, it was inactive against methicillin-resistant staphylococci (≥35 mg/1). Sch 34343 also had good activity against streptococci. The most unusual aspect of the in-vitro activity was its activity against Bacteroides (including Bact.fragilis ) and other anaerobes. Sch 34343 had mean MICs ≤0.l mg/1 for all Bacteroides and Clostridium spp tested except Cl. difficile (3.4 mg/1).

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