The Spectrum of Behavioral Responses to Cholinesterase Inhibitor Therapy in Alzheimer Disease
Open Access
- 1 November 1999
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 56 (11) , 1388-1393
- https://doi.org/10.1001/archneur.56.11.1388
Abstract
CHOLINESTERASE inhibitor therapy in Alzheimer disease (AD) may provide cognitive1,2 and behavioral symptomatic improvement for some patients.3,4 Not all patients respond to cholinergic therapy; there is a response distribution from marked to no improvement.5 If significant cognitive response is measured by an improvement of at least 7 points on the cognitive portion of the Alzheimer's Disease Assessment Scale,6 then 26% of patients with AD may respond to cholinesterase inhibitor therapy (using donepezil hydrochloride) in 24 weeks of treatment.5Keywords
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