Accuracy assessment of noninvasive hematocrit measurement based on partial least squares and NIR reflectance spectroscopy

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Abstract
Hematocrit (Hct) is one of the most important parameters to monitor when the patient has large blood loss or blood dilution. The current standard method for measuring hematocrit is off-line and invasive. An accurate, continuous, and noninvasive method of measuring hematocrit is highly desired for physicians to response rapidly in life-threatening situations. A set of instrumental characterization experiments was performed to assess the effects of spectrometer drift and probe placement on patient's forearm. Several factors were investigated in order to minimize the patient-dependent offset encountered in a previous study.

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