Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
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Open Access
- 15 July 2001
- journal article
- Published by American Society of Hematology in Blood
- Vol. 98 (2) , 428-435
- https://doi.org/10.1182/blood.v98.2.428
Abstract
Multiple myeloma (MM) remains incurable, with a median survival of 3 to 4 years. This study shows direct effects of vascular endothelial growth factor (VEGF) upon MM and plasma cell leukemia (PCL) cells. The results indicate that VEGF triggers tumor cell proliferation via a protein kinase C (PKC)–independent Raf-1–MEK–extracellular signal-regulated protein kinase pathway, and migration via a PKC-dependent pathway. These observations provide the framework for novel therapeutic strategies targeting VEGF signaling cascades in MM.Keywords
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