Sustained Delivery of Interleukin-2 from a Poloxamer 407 Gel Matrix Following Intraperitoneal Injection in Mice
- 1 January 1992
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 09 (3) , 425-434
- https://doi.org/10.1023/a:1015815624334
Abstract
Parenteral delivery of recombinant biologic response modifiers (BRMs) remains a challenge because of the brief intravascular half-life of most recombinant proteins and their associated rapid...Keywords
This publication has 20 references indexed in Scilit:
- Biological Activity of Urease Formulated in Poloxamer 407 after Intraperitoneal Injection in the RatJournal of Pharmaceutical Sciences, 1992
- SUSTAINED-RELEASE OF UREASE FROM A POLOXAMER GEL MATRIX1990
- Augmentation of the therapeutic efficacy of adoptive tumor immunotherapy by in vivo administration of slowly released recombinant interleukin 2Cancer Immunology, Immunotherapy, 1986
- Systemic administration of recombinant interleukin 2 stimulates in vivo lymphoid cell proliferation in tissues.The Journal of Immunology, 1985
- Interleukin 2 (IL 2) administered in vivo: influence of IL 2 route and timing on T cell growth.The Journal of Immunology, 1985
- Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2.The Journal of Experimental Medicine, 1985
- Successful immunotherapy of natural killer-resistant established pulmonary melanoma metastases by the intravenous adoptive transfer of syngeneic lymphocytes activated in vitro by interleukin 2.The Journal of Experimental Medicine, 1984
- Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.The Journal of Experimental Medicine, 1982
- Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2.The Journal of Experimental Medicine, 1982
- T‐Cell Growth FactorImmunological Reviews, 1980