The β‐Amyloid Precursor Protein (APP) and Alzheimer's Disease: Does the Tail Wag the Dog?
Open Access
- 1 September 2002
- Vol. 3 (11) , 763-770
- https://doi.org/10.1034/j.1600-0854.2002.31101.x
Abstract
The β-amyloid precursor protein has been the focus of much attention from the Alzheimer's disease community for the past decade and a half. The β-amyloid precursor protein holds a pivotal position in Alzheimer's disease research because it is the precursor to the amyloid β-protein which many believe plays a central role in Alzheimer's disease pathogenesis. It was also the first gene in which mutations associated with inherited Alzheimer's disease were found. Although the molecular details of the generation of amyloid β-protein from β-amyloid precursor protein are being unraveled, the actual physiological functions of β-amyloid precursor protein are far from clear. This situation is changing as accumulating new evidence suggests that the C-terminal cytosolic tail of β-amyloid precursor protein may have multiple biological activities, ranging from axonal transport to nuclear signaling. This article reviews the current state of knowledge about the biological functions of β-amyloid precursor protein.Keywords
This publication has 64 references indexed in Scilit:
- Insulin-degrading Enzyme Rapidly Removes the β-Amyloid Precursor Protein Intracellular Domain (AICD)Journal of Biological Chemistry, 2002
- A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60Science, 2001
- The β-Amyloid Precursor Protein Functions as a Cytosolic Anchoring Site That Prevents Fe65 Nuclear TranslocationJournal of Biological Chemistry, 2001
- Regulated Intramembrane ProteolysisCell, 2000
- What the evolution of the amyloid protein precursor supergene family tells us about its functionNeurochemistry International, 2000
- Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's β‐amyloid precursor proteinFEBS Letters, 1998
- Molecular mapping of alzheimer‐type dementia in Down's syndromeAnnals of Neurology, 1998
- Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to the dendritesJournal of Neuroscience Research, 1995
- Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons.The Journal of cell biology, 1995
- Alzheimer's DiseaseNew England Journal of Medicine, 1986