On the Occurrence of Methylcobalamine in Human Liver

Publisher Website
Google Scholar
Abstract
In 1961 Toohey & Barker reported findings suggesting that 5,6‐dimethylbenzimidazole‐coenzyme B12 (DMB‐coenzyme B12) may represent the bulk of the B12 content of the human liver. In investigations of the forms of B12 in normal human plasma Lindstrand & Ståhlberg (1963) discovered a predominant, labile form of B12, which they provisionally called the “fourth factor”. The finding was followed up by studies on pig's liver, in which they found a form of B12 showing the same lability and chromatographic properties as the fourth factor (Lindstrand & Ståhlberg 1963). The fourth factor in pig's liver is probably identical with methylcobalamine (Lindstrand 1964), and much suggests that this also holds true for the fourth factor in human plasma (Ståhlberg 1964)The finding of the fourth factor in human plasma and pig's liver prompted investigation of the types of B12 occurring in the human liver. The chromatographic and bioautographic techniques used revealed the occurrence of B12 forms with the chromatographic properties of methylcobalamine and DMB‐coenzyme B12.

This publication has 4 references indexed in Scilit: