Humoral Antibody Response and Tumor Transplantation Resistance Elicited by Fetal Tissues in Mice

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Abstract
Immune responses to fetal antigen immunization were studied in C57BLJ6 (B6), C3HJHeN (C3H), and BALBJc (BALB) mice. In tests by the isotopic antiglobulin technique, the mice could be grouped in three classes according to their antibody responses: good responders (86), poor responders (C3H), and nonresponders (BALB). In tumor transplantation experiments, protection against syngeneic tumor cell challenge, after fetal tissue immunization, was observed only with B6 mice. In addition, experiments on 86 mice showed that resistance to tumor challenge after fetal tissue immunization depended on the quantitative expression of fetal antigens by the tumor cells. Our results indicated that, in addition to other well-known factors, the effectiveness of fetal tissue immunization in tumor challenge resistance depended on both host reo sponsiveness and the amount of fetal antigen expressed by the tumor cells.

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