Biliary Cytodiagnosis Bile Sampling for Cytology

Abstract
Cohan RH, Illescas FF, Newman GE, Braun SD, Dunnick NR. Biliary cytodiagnosis: bile sampling for cytology. Invest Radiol 1985;20:177-179. The records of 121 patients who presented for PTC and biliary drainage within a five-year period were reviewed. Fifty-eight bile samples had been obtained from 38 of these patients for cytologic analysis. Malignancy was detected in 14 of 32 patients with carcinoma (sensitivity 44%). Repeat sampling was positive in four of nine patients whose initial specimen contained no tumor cells. Bile duct carcinoma, pancreatic carcinoma, and metastatic disease were all detected. An approach to biliary cytodiagnosis is offered that, it is hoped, will further minimize future false negative results.