Some Effects of Pressor-Antidiuretic and Oxytocic Fractions of Posterior Pituitary Extract on Sodium, Chloride, Potassium and Ammonium Excretion in the Dog

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Abstract
Pitressin (beta-hypoph-amine) administration to or withdrawal from water-loaded un-anesthetized dogs at 15-22 mU/hour was associated with corresponding increases or decreases in NaCl excretion of 0.05 to 0.35 mM/minute, the larger changes being associated, in general, with the larger control rates of Na excretion. K excretion changed in the same direction but the changes were less marked. Ammonium excretion did not change significantly. The same quantities of Pitressin had no effect on unhydrated animals. Pitocin (alpha-hypophamine) infusion at 25 mU/hr. had no effect. Electrolyte excretion changes did not correlate statistically with changes in glomerular filtration.