INFLUENCE OF HYPERTHYROIDISM ON URINARY EXCRETION OF THIAMIN AND RIBOFLAVIN1

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Abstract
Subcut. injs. of 0.5 to 1.0 mg. of synthetic thyroxin to adult albino rats for 17 to 21 days approx. trebled the excretion of riboflavin in the urine when comparison was made with litter mate control animals that did not receive thyroxin. Since hyper-thyroidism also produced large losses of body wt. and of riboflavin from many of the tissues, the increased excretion of riboflavin in the urine may have been caused by body tissue catabolism. Hyperthyroidism, however, caused negligible changes in the level of thiamin in the urine and much smaller losses of this vit. from the tissues. Incubation of liver, lung, heart, stomach, small intestine, and pancreas at 40[degree]C. for 48 hrs. resulted in a destruction of thiamin to the extent of 14, 17, 12, 26, and 20%, respectively. The decrease of thiamin content in several of the tissues may, therefore, have been caused by destruction by the tissues.

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