Inhibition of the Late Phase Reaction to Anti‐Human IgE in Man by Oral Tranexamic Acid
- 1 February 1984
- Vol. 39 (2) , 115-118
- https://doi.org/10.1111/j.1398-9995.1984.tb01942.x
Abstract
Pharmacologic modulation of the immediate and late phase reaction (LPR) to anti-human IgE was further investigated in a double-blind cross-over study. Tranexamine acid (AMCA) 1 g t.i.d. [2 times/day] 24 h prior to and following intradermal injection of anti-IgE produced .apprx. 40% inhibition of the LPR (P < 0.01) without affecting the early response as compared with placebo in 10 volunteers. Antagonistic effect on activation of fibrinolysis and possibly the complement system is suggested as a possible mode of action.Keywords
This publication has 23 references indexed in Scilit:
- The late phase of the immunoglobulin E-mediated reaction: a link between anaphylaxis and common allergic disease?Journal of Allergy and Clinical Immunology, 1982
- Effect in Man of Anti‐Allergic Drugs on the Immediate and Late Phase Cutaneous Allergic Reactions Induced by Anti‐IgEAllergy, 1981
- The Role of The Human Neutrophil in the Inflammatory ReactionAllergy, 1980
- Secretion of plasminogen activator by human polymorphonuclear leukocytes. Modulation by glucocorticoids and other effectors.The Journal of Experimental Medicine, 1977
- Urticaria and fibrinolysis*Clinical and Experimental Dermatology, 1977
- The late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies.Journal of Clinical Investigation, 1976
- Macrophage plasminogen activator: Modulation of enzyme production by anti-inflammatory steroids, mitotic inhibitors, and cyclic nucleotidesCell, 1976
- Late cutaneous allergic responses in isolated IgE-dependent reactionsJournal of Allergy and Clinical Immunology, 1973
- Experimental and Clinical Studies on AMCA, the Antifibrinolytically Active Isomer of p‐Aminomethyl Cyclohexane Carboxylic AcidScandinavian Journal of Haematology, 1965