The effect of chlorpromazine on cerebral glucose, ATP, ADP, AMP and ATPase in the mouse

Open Access
Publisher Website
Google Scholar
Abstract
1 Administration of chlorpromazine 10 mg/kg intraperitoneally to mice produced no alteration in cerebral adenosine triphosphate (ATP), adenosine diphosphate (ADP) or adenosine monophosphate (AMP). In these animals there was an increase in the glucose content of the supernatants of homogenates of liver and brain following acid hydrolysis. 2 Chlorpromazine 40 mg/kg intraperitoneally did not affect Mg++ activated adenosine triphosphatase (ATPase) activity in the brain.