Skin immune sentinels in health and disease
Top Cited Papers
- 18 September 2009
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 9 (10) , 679-691
- https://doi.org/10.1038/nri2622
Abstract
Human skin and the immune cells that it contains provide essential protection of the human body from injury and infection. Keratinocytes are a first line of defence and sense danger through alert systems such as the inflammasome and Toll-like receptors. They mediate an inflammatory response by secreting pro-inflammatory cytokines. A subpopulation of CD103+ dendritic cells is strategically positioned for cross-presentation of skin-tropic pathogens. Recent data have highlighted a key role of tissue-resident rather than circulating T cells in skin homeostasis and pathology. Important lessons for human skin immunology have been learnt from immunologically targeted therapies in inflammatory skin disorders such as psoriasis.Keywords
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