[Quality control of multicenter evaluation studies of the in vitro activity of antibiotics].

  • 1 June 1987
    • journal article
    • research article
    • Vol. 35, 687-91
Abstract
The estimation of the in vitro activity of an antibiotic, by different laboratories, requires the measurement, in standardized conditions, of the inhibition zone diameters versus a series of strains distributed to these laboratories (kits). Using the studies realized with two antibiotics, denoted by A and B, we observed an important variability between the different laboratories for a given strain and a less but still significant variability within the laboratories. Variance analysis revealed a significant interaction between strains and experimental laboratories. These results prevent the establishment of a standard diameter for a given strain but permit the quality control of the measurements and the improvement of the experimental design for future studies.

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