Plasma testosterone and androstenedione in insulin dependent patients at time of diagnosis and during the first year of insulin treatment

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Abstract
Ten male patients and 6 female patients with newly diagnosed insulin dependent diabetes mellitus and significant ketosis were studied before and during the 1st yr of insulin treatment. At onset, plasma concentrations of testosterone and androstenedione were significantly (P < 0.02) decreased in female patients when compared to healthy sex- and age-matched controls. Plasma concentrations of testosterone and androstenedione increased significantly (P < 0.001 and P < 0.05) in both sexes during insulin therapy. Plasma concentrations of testosterone were not significantly different from controls in both sexes after 4 days of insulin treatment and remained so during the 1st yr of insulin treatment. Plasma concentrations of androstenedione were not significantly different from controls in both sexes after 4 days of insulin treatment, but increased to levels significantly raised in both males (P < 0.001) and females (P < 0.05) after 7 days and during the 1st yr of insulin treatment.

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