EFFECT OF SINGLE AND MULTIDOSE CEPHRADINE PROPHYLAXIS ON INFECTIOUS MORBIDITY OF VAGINAL HYSTERECTOMY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 53  (1) , 31-35
Abstract
The administration of cephradine prophylactically to patients who were undergoing vaginal hysterectomies resulted in a marked and significant reduction in the incidence of post-operative infections when compared to a placebo group. Cephradine was the cephalosporin studied because of its unique pharmacodynamic properties, which result in high uterine tissue levels. The protective effect was similar whether 1 g was given pre-operatively followed by 500 mg i.v. every 6 h for 4 doses, or a single dose of 2 g i.v. given approximately 1 h before surgery. Uterine tissue and serum levels of antibiotic were high and correlated with the degree of protection noted.