Electrophysiological observations in patients with motor neuron disease receiving a thyrotropin releasing hormone analogue (RX77368).
- 1 December 1987
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 50 (12) , 1633-1640
- https://doi.org/10.1136/jnnp.50.12.1633
Abstract
Twenty nine patients with motor neuron disease receiving a thyrotropin releasing hormone analogue showed acute 25-30% increase in mean corrected fibre density and mean macro EMG median amplitude and area in brachial biceps muscle. The data are consistent with a direct or indirect action of the drug on anterior horn cells.This publication has 23 references indexed in Scilit:
- The effect of TRH on F waves recorded from antagonistic muscules in human subjectsAnnals of Neurology, 1985
- Motoneurone excitability during antidromically evoked inhibition after administration of a Thyrotrophin Releasing Hormone (TRH) analogueNeuropeptides, 1984
- Motoneurone excitability after administration of a thyrotrophin releasing hormone analogueBritish Journal of Pharmacology, 1983
- EFFECT ON WEAKNESS AND SPASTICITY IN AMYOTROPHIC LATERAL SCLEROSIS OF THYROTROPIN-RELEASING HORMONEThe Lancet, 1983
- Ventral root depolarization and spinal reflex augmentation by a TRH analog in rat spinal cordNeuropharmacology, 1982
- Biologically stable analogues of trh with increased neuropharmacological potencyNeuropharmacology, 1981
- IS THYROTROPIN RELEASING HORMONE AN ENDOGENOUS ERGOTROPIC SUBSTANCE IN THE BRAIN?The Lancet, 1981
- Actions of various gastrointestinal peptides on the isolated amphibian spinal cordCanadian Journal of Physiology and Pharmacology, 1979
- Stimulant action of thyrotropin releasing hormone on cat spinal cordNeuropharmacology, 1978
- Excitatory action of TRH on spinal motoneuronesNature, 1977