Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat
- 1 June 1999
- journal article
- research article
- Published by Wolters Kluwer Health in Pain
- Vol. 81 (3) , 307-316
- https://doi.org/10.1016/s0304-3959(99)00024-x
Abstract
Streptozotocin (STZ)-induced diabetes in the rat has been increasingly used as a model of painful diabetic neuropathy to assess the efficacies of potential analgesic agents. We have established this model, and here we question whether the changes in nocifensive reflex activity, used as a meaKeywords
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