Total synthesis of indole and dihydroindole alkaloids. XVI. Derivatives of vinblastine and vincristine: change of functionality in the vindoline unit
- 1 October 1978
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 56 (19) , 2560-2566
- https://doi.org/10.1139/v78-420
Abstract
Studies describing the preparation of various derivatives of vinblastine and vincristine are presented. Vindoline [readily available from Catheranthus roseus] is transformed into a series of derivatives and the latter via Polonovski-type coupling with catharanthine provide the bisindole alkaloid derivatives of the vinblastine series. Selective Jones'' oxidation transforms the vinblastine family into the corresponding vincristine derivatives.This publication has 3 references indexed in Scilit:
- Alkaloids of Vinca rosea L. (Catharanthus roseus G. Don). 38. 4'-Dehydrated derivativesJournal of Medicinal Chemistry, 1977
- Total Synthesis of Indole and Dihydroindole Alkaloids. IX Studies on the synthesis of bisindole alkaloids in the vinblastine‐ vincristine series. The biogenetic approachHelvetica Chimica Acta, 1976
- Application of a modification of the Polonovski reaction to the synthesis of vinblastine-type alkaloidsJournal of the American Chemical Society, 1976