Serologic Response of Individuals Infected with Para Influenza Viruses
- 1 December 1960
- journal article
- research article
- Published by American Public Health Association in American Journal of Public Health and the Nations Health
- Vol. 50 (12) , 1858-1865
- https://doi.org/10.2105/ajph.50.12.1858
Abstract
An evaluation of the hemagglutination inhibition and neutralization technics revealed them to be sensitive serologic procedures for the diagnosis of infection by para influenza 1 and 3 viruses. Complement fixation proved to be a sensitive method for serodiagnosis of para influenza 3 infection but not for para influenza 1 infection unless the associated illness was of a severe nature. Etiologic diagnosis by serologic means was hampered by the occurrence of heterotypic responses, which were more commonly observed following para influenza 1 infection. Of the two methods examined for such heterotypic responses, the hemagglutination inhibition technic was preferable to the complement-fixation procedure, since the latter test tended to underestimate the occurrence of para influenza 1 infection and to overestimate para influenza 3 infection. In view of the 20% heterotypic response rate observed in the hemagglutination inhibition test, it would appear that specific etiologic diagnosis can best be established by virus isolation.Keywords
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