L‐Proline Inhibition of Glutamate Release

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Abstract
The influence of 1 mm‐l‐proline on electrically stimulated release of endogenous glutamate from slices of rat frontal cortex was measured. One mm‐l‐proline approximates the in vitro concentration that inhibits glutamate‐induced spreading depression. Also, this l‐proline level has been reported to be present in brain after an intraperitoneal injection that induced amnesia in chicks. l‐Proline but not d‐proline exhibits an inhibitory effect on glutamate release, thus supporting the suggestion that this mechanism may play a role in memory retention and/or formation.