Passive transfer of the idiotypically suppressed state by serum from suppressed mice and transfer of suppression from mothers to offspring.

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Abstract
Mice that are suppressed with respect to an idiotype (CRI [major intrastrain cross-reactive idiotype associated with anti-p-azophenylarsonate antibodies of A/J mice]) present in A/J anti-p-azophenylarsonate [Ar] antibodies, hyperimmunized and allowed to rest were previously found to possess high concentrations of suppressor T cells with anti-idiotypic receptors. The sera of such mice contain soluble factors that can selectively suppress the CRIA component of a humoral response when passively transferred to adult or neonatal recipients. When T cells from suppressed, hyperimmunized mice were transferred into female mice before mating, their offspring, upon immunization, produced anti-Ar antibodies that lacked CRIA. A state of idiotypic suppression was also produced in offspring when the mother was inoculated with serum from suppressed mice a few days before parturition. The suppressor factor is apparently not an Ig.