Thyroid Disorders—A Half Century of Innovation

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Abstract
Substitution therapy with thyroid hormone effectively controls myxedema and is suitable treatment for most cases of thyroid enlargement, including thyroid nodules and chronic lymphocytic thyroiditis; many cases of subacute thyroiditis are benefitted and the rest respond to therapy with adrenal corticoids. Antithyroid drugs control hyperthyroidism but about one-half of cases suffer a relapse when treatment is stopped. Radioiodine is thoroughly effective but the rising incidence of myxedema will restrict its application unless means are found to avoid it.

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