Antifibrotic effect ofStephania tetrandra on experimental liver fibrosis induced by bile duct ligation and scission in rats

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Abstract
We examined the antifibrotic effect of a methanol extract fromStephania tetrandra (ST) on experimental liver fibrosis. Liver fibrosis was induced by bile duct ligation and scission (BDL/S) in rats. In BDL/S rats, activity levels of aspartate transaminase (AST), alanine transaminse (ALT), alkaline phosphatase (ALP), concentration of total bilirubin in serum, and hydroxyproline content of the liver were significantly increased. The ST treatment (either 100 mg/kg/day or 200 mg/kg/day, p.o. for 4 weeks) in BDL/S rats reduced the serum AST, ALT and ALP activity levels significantly (pS. tetrandra, had an antifibrotic effect in rats with liver fibrosis induced by bile duct ligation and scission.