EFFECT OF URINARY pH AND NICOTINE EXCRETION RATE ON PLASMA NICOTINE DURING CIGARETTE SMOKING AND CHEWING NICOTINE GUM
Open Access
- 1 April 1978
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 5 (4) , 293-297
- https://doi.org/10.1111/j.1365-2125.1978.tb01710.x
Abstract
Plasma nicotine levels produced by chewing nicotine gum were compared with those obtained by cigarette smoking under conditions of controlled urinary pH. Although absorption was slower, plasma levels comparable to cigarette smoking were built up on 4 mg (but not 2 mg) nicotine gum. Urinary excretion of nicotine was influenced markedly by pH and the rate of urine flow. Plasma nicotine was higher under alkaline compared to acidic conditions (P < 0.001) but the rate of urinary nicotine excretion appeared to have little effect on the plasma level.Keywords
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