Crystal and molecular structure of acetazolamide (5-acetamido-1,3,4-thiadiazole-2-sulphonamide), a potent inhibitor of carbonic anhydrase
- 1 January 1974
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 5,p. 532-536
- https://doi.org/10.1039/p29740000532
Abstract
Crystals of the title compound, a potent inhibitor of carbonic anhydrase, are colourless, triclinic, with unit-cell dimensions, a= 5·318(4), b= 9·065(4), c= 9·430(7)Å, α= 105·44(2), β= 98·59(2), γ= 100·42(2)°, Z= 2. The structures was solved by the heavy-atom method and refined by least-squares techniques to a final R of 0·028 for 1054 observed reflections. The distances and angles are compared with those in other sulphonamides of varying biological activity. The mechanism of inhibition of carbonic anhydrase is discussed.Keywords
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