Methylenebutyryl Phenoxyacetic Acid

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Abstract
PHARMACOLOGICAL AGENTS which increase salt and water excretion by the kidney represent one of the most significant therapeutic advances in the past decade. Investigation of the nature of the action of these drugs has helped to clarify the mechanisms involved in renal transport of electrolyte and water and has provided information about the homeostatic processes controlling salt and water balance, upset of which results in edema formation. Four major categories of diuretics which act on renal tubular transport systems are recognized: (1) the organic mercurials, (2) the chloruretic sulfonamides (thiazide derivatives), (3) sulfonamides which inhibit carbonic anhydrase, and (4) aldosterone antagonists, —17 spironolactones. Recently, a chemically different group of agents has been developed, alpha, beta unsaturated ketone derivations of aryloxyacetic acids.1 These compounds were found to be highly effective diuretic agents when administered to the dog, but were inactive in the rat. Compounds of the group with a significant

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