REDUCTION OF INCREASED INTRACRANIAL PRESSURE BY CONCENTRATED SOLUTIONS OF HUMAN LYOPHILE SERUM

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Abstract
From theoretical considerations, the ideal hypertonic solution for reducing intracranial pressure is one that not only has a high osmotic pressure but contains solutes which will remain in the blood vessels after injection to exert a continued osmotic effect. The normal impermeability of the blood capillaries in man to serum proteins suggested that a hypertonic solution of blood serum would more closely approximate these theoretical requirements than do solutions in current use. On purely physiologic grounds such a preparation should be clinically useful, on the one hand, for reduction of increased intracranial pressure and, on the other, for restoration of low blood pressure resulting from shock, burns or hemorrhage. The results of the use of concentrated human blood serum in reducing cerebrospinal pressure is the subject of this report. PREPARATION OF CONCENTRATED SERUM Several technics have been devised for desiccating normal blood serum: those of Elser, Thomas and Steffen;1

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