Inhibition of the Uptake of Biogenic Amines into Mast Cells by Tricyclic Psychoactive Drugs
- 1 August 1971
- journal article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 85 (4) , 446-454
- https://doi.org/10.1111/j.1748-1716.1971.tb05282.x
Abstract
The inhibitory effect of tricyclic neuroleptic and antidepressant drugs was investigated on the uptake of 14C‐labelled 5‐hydroxytryptamine (5‐HT), dopamine (DA), noradrenaline (NA) and histamine (Hi) by isolated rat mast cells. All drugs inhibited the amine uptake but varied quantitatively and qualitatively in their blocking effects. Results showed that 5‐HT and NA uptake were competitively inhibited by both neuroleptics and antidepressants, whereas DA uptake only seemed competitively inhibited by neuroleptics.Keywords
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