Blood Levels of Bupivacaine after Injection into the Scalp with and without Epinephrine

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Abstract
Infiltration into the scalp of a local anesthetic is often done for the surgical excision of a seizure focus. This will result in the appearance of the drug in the systemic circulation. Since local anesthetics have anticonvulsant activity, systemic absorption might result in blood levels sufficient to decrease seizure activity and interfere with the localization of the seizure focus. Higher blood concentrations may be associated with symptoms of local anesthetic toxicity. Observations were presented on blood levels of bupivacaine in patients following s.c. infiltration into the scalp of 0.125% and 0.25% solutions with and wihtout epinephrine, 1:400,000.

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