Novel stereoselective alkylation of 4-t-butylcyclohexanone using trimethylaluminium in benzene
- 1 January 1971
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society D: Chemical Communications
- No. 7,p. 351-352
- https://doi.org/10.1039/c29710000351
Abstract
Although alkylation of 4-t-butylcyclohexanone in tetrahydrofuran and diethyl ether using Me2Zn, Me2Cd, Me2Mg, MeMgX (where X = F, Cl, Br), and Me3Al produces predominantly the cis-alcohol (ca. 75% in tetrahydrofuran), alkylation using Me3Al in benzene at a Me3Al: ketone ratio of 2:1 or greater produces predominantly (ca. 90%) the trans-alcohol.Keywords
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