Effect of inhibition of prostaglandin synthesis on induced bronchial hyperresponsiveness.

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Abstract
Two groups of normal subjects were immunized with live attenuated influenza virus given by the intranasal route. One group was then treated with placebo capsules for 48 h. At the end of this time an increase in sensitivity to inhaled histamine was found but with a coincident decrease in reactivity. The other group was treated with indomethacin (50 mg 4 times daily). The increase in sensitivity associated with influenza vaccination was prevented but there was a significant increase in reactivity. Prostaglandins released as part of the inflammatory response in the airways after viral infection may be concerned in induction of the changes in the response to histamine observed under these conditions.