The Primary Structure of the Constant Part of μ‐Chain‐Disease Protein BOT

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Abstract
The complete primary structure of the constant part of the .mu. chain disease protein, BOT, was established. It includes the whole CH2, CH3 and CH4 domains. Two amino acid changes were found, at positions 309 (Ser .fwdarw. Gly) and 333 (Val .fwdarw. Gly) (GAL numbering). In 2 additional monoclonal .mu. chains (SCO and CO), the same positions showed an amino acid variability. From these data it may be concluded that 4 types of .mu. chains exist in the human: GAL type with Ser-309 and Val-333; OU type with Gly-309 and Val-333. SCO type with Ser-309 and Gly-333; and BOT/CO type with Gly-309 and Gly-333. The meaning of this molecular polymorphism is discussed.