GROWTH AND PUBERTAL DEVELOPMENT IN 5 BOYS WITH NOONANS SYNDROME
- 1 January 1982
- journal article
- research article
- Vol. 57 (1) , 13-17
Abstract
Five boys, each with at least 4 features characteristic of Noonan''s syndrome, were studied throughout childhood. In each the height was on or below the 3rd centile. Height velocity was essentially normal during the prepubertal period whereas bone age and pubertal development were delayed. Four boys had cryptorchidism and in 2 no testicular enlargement or spontaneous puberty occurred, necessitating testosterone replacement. Plasma concentrations of luteinizing hormone and FSH before and after stimulation withe LHRH were increased in 4 of the boys. These findings are consistent with primary gonadal failure associated with impaired spermatogenesis.This publication has 13 references indexed in Scilit:
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