Both Lumenal and Cytosolic Gating of the Aqueous ER Translocon Pore Are Regulated from Inside the Ribosome during Membrane Protein Integration
Open Access
- 1 July 1997
- Vol. 90 (1) , 31-41
- https://doi.org/10.1016/s0092-8674(00)80311-6
Abstract
No abstract availableKeywords
This publication has 30 references indexed in Scilit:
- The Aqueous Pore through the Translocon Has a Diameter of 40–60 Å during Cotranslational Protein Translocation at the ER MembraneCell, 1997
- Discrete Cross-linking Products Identified during Membrane Protein BiosynthesisJournal of Biological Chemistry, 1997
- The Cotranslational Integration of Membrane Proteins into the Phospholipid Bilayer Is a Multistep ProcessCell, 1996
- Sequence-Specific Alteration of the Ribosome–Membrane Junction Exposes Nascent Secretory Proteins to the CytosolCell, 1996
- NAC covers ribosome-associated nascent chains thereby forming a protective environment for regions of nascent chains just emerging from the peptidyl transferase center.The Journal of cell biology, 1995
- The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the ER membrane early in translocationCell, 1993
- A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation.The Journal of cell biology, 1991
- Unusual Topogenic Sequence Directs Prion Protein BiogenesisScience, 1990
- Protein translocation across the endoplasmic reticulum membrane: identification by photocross-linking of a 39-kD integral membrane glycoprotein as part of a putative translocation tunnel.The Journal of cell biology, 1989
- Partial resistance of nascent polypeptide chains to proteolytic digestion due to ribosomal shieldingJournal of Molecular Biology, 1967