Effect of Ergotamine on Milk-Ejection in Lactating Rat.

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Abstract
1. The quantity of milk secured in 20 minutes by litters of ergotamine-treated rats on the first of 4 days treatment was small in comparison to that obtained by control offspring on the same day. The difference was significant. This difference progressively diminished, however, following additional treatment on the following 3 days, as the animals became more resistant to the drug. The average amount of milk obtained by experimental animals over the 4-day period of treatment, nevertheless, was significantly less than that obtained over the same period by control offspring. 2. The possible mechanism by which ergotamine interferes with “let-down” of milk from rat mammary gland is discussed.

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