Pemphigus-like antibodies in bullous pemphigoid

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Abstract
A patient had clinical, histopathologic and direct immunofluorescent findings compatible with a diagnosis of bullous pemphigoid. The patient''s serum contained pemphigus-like antibodies with different antigenic specificities than true pemphigus antibodies. Absorption of the patient''s serum with AB [antibody] substance failed to block the intercellular substance staining but allowed the demonstration of a basement membrane zone reactive antibody as well. Atypical cases such as this should not cast doubt on the usefulness of immunofluorescence in the diagnosis of bullous skin diseases.

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