The V(D)J Recombination in Acute Lymphoid Leukemias: A Short Review

1 January 1994

journal article
Published by Taylor & Francis in Leukemia & Lymphoma

Vol. 13 (sup1) , 53-57
https://doi.org/10.3109/10428199409052675

Abstract

Antigen recognition by lymphoid cells is mediated by cell surface receptors. Specificity of this recognition is due to somatic gene rearrangements. These recombinations involve gene segments (V, J and in some cases D) which encode the amino terminal part of antigen receptor chains. Surface immunoglobulins (sIg) function as antigen receptors for B cells. Two types of T cell antigen receptors (TCRαβ and TCRγδ) have been described whose expression at the cell surface of T cells is exclusive. V(D)J rearrangements are clone specific and occur irrespective of antigens during the early stages of lymphoid differentiation. In rare instances, recombination occurs between different Ig/TCR loci or even involve genes distinct of those coding for Ig or TCR. In some cases these genes are activated by the chromosomal rearrangement and could be involved in the transformation of lymphoid cells.

Keywords

This publication has 17 references indexed in Scilit:

VDJ recombination
Immunology Today, 1992
Unexpected consistent involvement of V beta gene segments in inappropriate T-cell receptor beta gene rearrangements occurring in B- lineage acute lymphoblastic leukemias
Blood, 1992
Interlocus V-J recombination measures genomic instability in agriculture workers at risk for lymphoid malignancies.
Proceedings of the National Academy of Sciences, 1992
Expression of human recombination activating genes (RAG1 and RAG2) in neoplastic lymphoid cells: correlation with cell differentiation and antigen receptor expression
Blood, 1991
Detection of T-cell receptor gamma chain V gene rearrangements using the polymerase chain reaction: application to the study of clonal disease cells in acute lymphoblastic leukemia
Blood, 1991
Use of oligonucleotide probes directed against T cell antigen receptor gamma delta variable-(diversity)-joining junctional sequences as a general method for detecting minimal residual disease in acute lymphoblastic leukemias.
Journal of Clinical Investigation, 1990
Inversion of chromosome 7 in ataxia telangiectasia is generated by a rearrangement between T-cell receptor beta and T-cell receptor gamma genes
Blood, 1989
Detection of minimal residual disease in acute lymphoblastic leukemia by in vitro amplification of rearranged T-cell receptor delta chain sequences
Blood, 1989
Detection of minimal disease in hematopoietic malignancies of the B-cell lineage by using third-complementarity-determining region (CDR-III)-specific probes.
Proceedings of the National Academy of Sciences, 1989
Human T cell gamma genes are frequently rearranged in B-lineage acute lymphoblastic leukemias but not in chronic B cell proliferations.
The Journal of Experimental Medicine, 1987