Studies on a Strain of Chloroquine-Resistant Plasmodium Falciparum from Colombia, South America

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Abstract
Summary We have confirmed that, after passage through mosquitoes, a strain of Plasmodium falciparum from Colombia, South America, is resistant to standard doses of chloroquine, hydroxychloroquine, and amodiaquine, and that radical cure of infections with this strain can be achieved by the administration of either pyrimethamine or quinine. The Colombia strain is resistant to BW 377C54, a hydroxynaphthalene derivative known to be effective against chloroquine-resistant Plasmodium berghei in mice. Preliminary investigations suggest that the concurrent weekly administration of primaquine and chloroquine, although ineffective for treatment of patent infections, may be effective in preventing patency of moderately-seeded, mosquito-induced infections of this strain.

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