Fibrinolysin (Plasmin) Therapy in Acute Deep Thrombophlebitis
- 1 March 1960
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 21 (3) , 337-353
- https://doi.org/10.1161/01.cir.21.3.337
Abstract
Sixty-two patients with deep thrombophlebitis of less than 10 days' duration were studied in controlled fashion. Thirty "control" patients were treated by routine methods including anticoagulant drugs. Thirty-two "treatment" patients received fibrinolysin (plasmin) in addition to control therapy. The composition of the groups studied and the protocol followed are presented in detail. Comparison of the 2 groups indicates that the addition of fibrinolysin to the therapeutic regimen leads to more rapid clearing of the acute phlebitic episode and may diminish the short-term incidence of phlebitic recurrence and pulmonary embolization. Postphlebitic residuals were encountered with almost equal frequency in both groups. Greater short-term differences in therapeutic response exist between control and fibrinolysin patients when analysis is restricted to those treated within 5 days of phlebitic onset. The available data do not permit firm conclusions regarding the apparently favorable influence of fibrinolysin upon the long-term prognosis of phlebitic subjects, but do indicate that recurrence and embolization can be expected in both groups. The factors that may influence the results obtained with fibrinolytic therapy are discussed and the importance of considering them in studies of this type is emphasized.Keywords
This publication has 4 references indexed in Scilit:
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- THE VARIED CLINICAL MANIFESTATIONS OF PULMONARY EMBOLISMAnnals of Internal Medicine, 1957
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- THE USE OF DICUMAROL AS AN ANTICOAGULANT: EXPERIENCE IN 2,307 CASESAnnals of Internal Medicine, 1947